Coflore ACR

Laboratory Scale Flow Reactor

The Coflore® Agitated Cell Reactor (ACR) is a bench-top flow reactor for developing scalable flow chemistry solutions in a laboratory environment.

The Coflore ACR is a mechanically agitated flow reactor with a reactor channel divided into ten stages, operating as ten CSTRs in series for plug flow performance. Coflore technology provides efficient active-mixing even at very low flow rates, providing versatility for handling a variety of liquid, liquid-liquid, solid-liquid, liquid-gas, and solid-liquid-gas reaction mixtures, including dense slurries.

The Coflore ACR flow reactor is ideal for establishing and developing continuous processes prior to scale up, or when only limited quantities of material are available or required. Processes developed on an ACR platform have a straight-forward path to scale up via the larger-volume Coflore ATR and Coflore RTR pilot and production scale flow reactors.

Highly configurable – Options include co- and counter- current cell blocks, built from a variety of robust and chemically-resistant materials of construction. Working reactor volumes from 30 to 100 mL are interchangeable with minimal configurational changes to the reactor assembly.

Cleanable – All wetted surfaces and components are easily accessible, sanitised, and cleaned.

Versatile – Compatible with a wide scope of chemical processes for residence times ranging from seconds to hours. Multi-phase mixtures including slurries and gases can be processed with low risk of blocking or fouling.

Simple to use – Minimal set up required.  Residence time is determined by the pump flow rate and not the size or length of the reactor process channels. Mixing and plug flow performance is maintained by default, irrespective of flow rate.

Wide pump compatibility – Low pressure drops for process and heat transfer fluids, greatly expanding choice of pumps.

A tool for lab chemistry – Cell reactor contents can be observed through glass windows. Reagents can be added, or samples removed and analysed at each of the ten reactor cells. Operates with low working volumes, using simple controls.

Coflore ACR Digital Version

Coflore ACR Reactor Block

Coflore ACR Features and Specifications:

  • Working volumes: 30 mL, 50 mL, 70 mL, 100 mL

  • Residence time: seconds to >8 hours

  • Mixing (process side): Active mixing

  • Mixing (heat transfer side): Active mixing

  • Agitation speed: 2 – 9 Hz

  • Number of mixed stages: 10

  • Reactor temperature: - 40 to 140 ˚C

  • Pressure: up to 10 Bar

  • Wetted materials: 316 Stainless steel, Hastelloy C276, PTFE

  • Production scale: Grams to kilograms

  • Throughput: 0.1 mL/min to 300 mL/min

  • Addition/sample points: 10 side ports, one for each cell

  • Containment: Stainless steel enclosure with extractor connection

  • Temperature monitoring: Up to 10 points, one for each cell

  • Data logging: Programmable process parameter recording 

The Coflore ACR Cell Block (ACR-100) is the standard cell block with a nominal working volume of between 30 to 100 mL. Reactor volume is determined and adjusted using appropriately sized cylindrical agitators within each of the ten reaction cells, occupying 30%, 50% or 70% of the cell volume.  High-shear agitators are used to give a working reactor volume of 100 mL.

Fabricated from 316 stainless steel, Hastelloy C276 or PTFE, the ACR-100 cell block is comprised of ten inter-connected reaction stages in series, featuring borosilicate glass viewing windows, side and front addition and sampling ports at each cell, and multi-point temperature measurement. The ACR-100 cell block is positioned within the ACR reactor block assembly, which is in turn mounted onto the ACR agitating platform within the ACR control cabinet.

The ACR-100 cell block is ideally suited to processing homogeneous and multi-phase mixtures, including dense slurries.

 

ACR-100 Dimensions:

  • Reactor volume: 30 to 100 mL

  • Cell diameter: 25 mm

  • Cell depth: 20 mm

  • Process channel size: 4 x 4 mm

  • No. of inter-connected process channels: 11

Coflore ACR Reactor Block (Exploded View)

The Coflore ACR Counter-Current Cell Block (ACX-100) is used for counter-current operations, including counter-current extraction, for multiple phases flowing in opposite directions along the reaction path. The ACX-100 replaces the ACR-100 cell block inside the ACR reactor block assembly.

Continuous counter-current extractors give higher extraction efficiency with lower solvent usage when compared to standard co-current configurations. 

Fabricated from 316 stainless steel, Hastelloy C276 or PTFE, the AXR-100 cell block is comprised of ten inter-connected reaction stages in series, featuring borosilicate glass viewing windows, side and front addition and sampling ports at each cell, and multi-point temperature measurement. The AXR-100 cell block is positioned within the ACR reactor block assembly, which is in turn mounted onto the ACR agitating platform within the ACR control cabinet.

ACX-100 Dimensions:

  • Reactor volume: 30 to 100 mL

  • Cell diameter: 25 mm

  • Cell depth:  20 mm

  • Process channel size: 4 x 4 mm

  • No. of process channels: 20

Coflore ACR-100 and AXR-100 Cell Blocks

(Co-Current and Counter-Current)

Coflore ACR Reactor Block, Mounting Plate and Socket

Coflore ACR Technical Specifications:

Digital Control Features and Specifications​:

  • Temperature Display with up to 10 thermocouple inputs and 10 temperature displays

  • Programmable Alarm for high and low temperature set points

  • Ethernet Connection enabling remote control via PC

  • Start/Stop Agitation with 8 agitation frequencies: 2,3,4,5,6,7,8,9 Hz

  • Remote DCS/PLC Interface for remote agitation control with local and remote emergency stop

  • Pump Control for up to 3 pumps via a 4 - 20 mA signal to include: start/stop, set point 0 - 100%, pump flow rate totaliser & automatic pump control

  • Actuated Valve Control for up to 2 actuated valves to include: open / close time & flow rate totaliser

  • 4 - 20 mA Input Monitoring for to 4 input signals measuring 4 - 20 mA from 0 - 100%

  • Data Logging for process monitoring & data export to MS Excel

  • ATEX certification and CFR21 compliance options available on request

Technical Specifications​:

  • Maximum reactor mass: 9 kg

  • Agitating platform mass: 130 kg

  • Noise: < 70 dBA

Requirements:

  • Compressed air: 3 bar, 3.2 CFM oil free clean air

  • Maximum air pressure: 6 bar

  • Power supply: 100-240 VAC 50/60 Hz 2A

  • Compressed air connection: 6 mm push fit

  • Heat transfer fluid connections: M16 x 1.0 Huber

Dimensions:

  • Height: 430 mm

  • Width:  655 mm

  • Length: 480 mm

Anti-Vibration Table:

  • Height: 655 mm

  • Width:  1062 mm

  • Length: 762 mm

655 mm

1085 mm

726 mm

480 mm

1062 mm

430 mm

655 mm

Coflore ACR Dimensions:

ACR Cover.PNG

Coflore ACR® Product Brochure

Open

Download

Coflore ACR® Accessories Brochure

Open

Download

AM Technology, Cheshire, UK
robert.field@amt.uk
+44 1928 237420