Coflore Agitated Tube Reactor (ATR)

Pilot Scale

The Coflore ATR is an actively-mixed tubular flow reactor that employs the same mixing principles as the smaller ACR reactor.  The Coflore ATR operates from 0.35 L to 10 L in reactor volume, and has been developed for the pilot-scale production of material. Configured of up to eight reactor tubes in series, the ATR flow reactor exhibits excellent plug-flow, with experimental data demonstrating well-over 100 theoretical stages.  Each of the eight tubes can be heated or cooled independently of each other and reagents can be added (or samples removed) at each end of each reaction tube. 

The Coflore ATR can handle a wide range of reagent mixtures; even those with heavy slurries without blocking, making it ideal for a wide range of processes including hydrogenation, which can be fully-automated for ease-of-use and safety.

For a 5-minute residence time, the Coflore ATR can continuously produce up to 120 L per hour, or 2,880 L continuously per day.

The Coflore ATR  is a flexible, versatile and and efficient plug-flow reactor. Its unique characteristics stem from the use of radial mechanical stirring rather than passive mixing. This approach decouples plug-flow and mixing from residence time, to give very low dispersion numbers, fast blending and high shear.

Coflore ATR® Specifications:

  • Working volume: 350 mL to 10 L

  • Residence time: 10 seconds to >8 hours

  • Mixing (process side): Active mixing

  • Agitation speed: 2 – 9 Hz

  • Number of theoretical stages: >100

  • Reactor temperature: -40oC to +140oC (+200oC optional)

  • Pressure: up to 50 Bar

  • Wetted materials: Stainless steel, Hastelloy

  • Production scale: Kilograms to multi-tonne

  • Throughput: 0.1 L/min to 30 L/min

  • Addition points: 16, two for each tube

  • Containment: Stainless steel enclosure with extractor connection

  • Temperature monitoring: Up to 16 points

  • Data logging: Programmable process parameter recording 

  • Alarm function: Set high or low alarms

The Coflore ATR® (Digital Version)

Coflore ATR® Features

  • Reaction time from seconds to over 10 hours

  • Slurries, immiscible fluids and gas/liquid mixtures, as well as liquid-liquid

  • Plug flow equivalent to >100 stirred tanks in series (1 hour reaction time in <3 metres of tube)

  • Mass transfer rates 1-2 orders of magnitude higher than large batch reactors

  • Blending times 1-2 orders of magnitude faster than batch reactors

Coflore ATR® Reactor Tube with cut-away showing agitator

Reactor Tube (0.35 L or 1.25 L):

  • Vertical Reactor Tube Connection - short vertical connections couple together reaction tubes with minimal unmixed volume

  • Reactor Tube Agitator - gives radial mixing for excellent orderly flow

  • Heat Transfer Inlet/Outlet - two per reactor tube

  • Reactor Tube End Cap - 1/2" triclover connection with 9.5 mm ID inlet

Reactor Tube Inlet/Outlet Connectors:

  • Reactor Tube End Cap - 1/2" triclover connection with 9.5 mm ID inlet

  • Injection Plug - used to adapt from 1/4" BSPP to 1/4" - 28 UNF thread

  • 9.5 mm Triclover Adaptors - adapt from a 1/2" triclover to a 1/4" BSPP with a 9.5 mm through-hole

  • Hose Barb Adaptors - adapt from a 1/2" triclover to a hose-barb to suit 4.8 mm ID tubing

Reactor Tube Assembly showing various inlet/outlet connectors

Coflore ATR® Reactor Tube Assembly

8 x 1.25 L Tubes. Available in Stainless Steel and Hastelloy

The Coflore ATR® Reactor Tube Assembly is comprised of the following:

  • Reactor Tube Frame - easily removed and interchanged to install different reactor tube configurations

  • Heat Transfer Manifold - tubes can be heated and cooled independently of each other

  • Reactor Tube Bank - up to two per agitating table, with up to four vertical reactor tubes per back

  • Vertical Reactor Tube Connections - short vertical connections couple together reaction tubes with minimal unmixed volume

  • ATR Reactor Tube - available in 0.35 mL and 1.25 L volumes. Two inlets/outlets per reactor tube are used for injection/extraction and process parameter measurement (e.g. temperature)

  • Heat Transfer Jacket - one per reactor tube for flexible overall reactor temperature control and multiple temperature zones

Digital Control Features  and Specifications

  • Temperature Display with up to 10 thermocouple inputs and 10 temperature displays

  • Programmable Alarm for high and low temperature set points

  • Ethernet Connection enabling remote control via PC

  • Start/Stop Agitation with 8 agitation frequencies: 2,3,4,5,6,7,8,9 Hz

  • Remote DCS/PLC Interface for remote agitation control with local and remote emergency stop

  • Pump Control for up to 3 pumps via a 4 - 20 mA signal to include: start/stop, set point 0 - 100%, pump flow rate totaliser & automatic pump control

  • Actuated Valve Control for up to 2 actuated valves to include: open / close time & flow rate totaliser

  • 4 - 20 mA Input Monitoring for to 4 input signals measuring 4 - 20 mA from 0 - 100%

  • Data Logging for process monitoring & data export to MS Excel

  • ATEX certification and CFR21 compliance options available on request


  • Compressed air: 3-7 bar, 13 CFM oil free clean air

  • Maximum air pressure: 7 bar

  • Power supply: 1ph + N+E 100-240 VAC 50/60 Hz 2A

  • Compressed air connection: 10 mm push fit

  • Heat transfer fluid connections: 1/2” Swagelok

Technical Specifications​:

  • Maximum reactor mass: 120 kg

  • Agitating platform mass: 150 kg

  • Noise: < 70 dBA

ATR Dimensions:

  • Height: 1800 mm

  • Width:   1200 mm

  • Length:   780 mm

1200 mm

780 mm

1800 mm

1700 mm

ATR Cover.png
ATR Accessories Brochure Cover.PNG

The Coflore ATR® Accessories Brochure



Flow Reactors for the Chemical and Pharmaceutical Industries

AM Technology, Cheshire, UK
+44 1928 237420