Coflore RTR

Production Scale Flow Reactor

The Coflore® Rotating Tube Reactor (RTR) combines the benefits of flow and batch chemical processing within a single flow reactor. 

The Coflore RTR has a 100 L capacity that is capable of processing countless reactor volumes without interruption.  For a 5-minute residence time, the RTR can produce 1,200 L continuously per hour, or 28,800 L continuously per day.  Such throughputs have the potential to produce many thousands of tonnes of material per year.   An easy route from laboratory optimisation and feasibility to production has been established in conjunction with the smaller Coflore ACR and ATR flow reactors.

The Coflore RTR operates as a ten-stage, actively-mixed, self-baffling continuous flow reactor with efficient orderly-flow characteristics.  According to the CSTRs in series model, the RTR flow reactor behaves as ten theoretical stages.

The Coflore RTR incorporates the productivity, scalability and versatility attributes of batch, with the efficiencies of flow, within a single flow reactor.

Easy to clean and sterilise

The reactor unit is easily disassembled and reassembled to facilitate efficient cleaning and sterilisation of all wetted components, including the agitator.

Intrinsic Safety

The RTR enclosure operates a safety protocol whereby access to the reactor is only possible once the critical system components of the reactor have been completely shut down.

Heating/cooling (-40 to 150 ˚C)

The three-zone jacket delivers excellent heat-transfer performance with the option of tuning the heating and cooling conditions to suit the reaction kinetics.  Each temperature zone can be heated or cooled independently of each other.



The inertia mixing and efficient heat-transfer performance of the Coflore RTR enable it to effectively process multi-phase reaction mixtures, including liquid-liquid, liquid-gas, solid-liquid and solid-liquid-gas.

​Coflore RTR Specifications:

  • Working volume: 100 L

  • Reactor temperature: - 40 to 150 ˚C

  • Pressure: up to 10 Bar

  • Residence time: <1 minute to many hours

  • Mixing : Active mixing

  • Number of mixed stages: 10

  • Wetted materials: 316 Stainless steel, Hastelloy C276

  • Production scale: Kilogram to multi-tonne

  • Throughput: 0.1 L/min to 200 L/min

  • Addition/sample points: 10 process ports

  • Temperature monitoring: Up to 10 points

  • Data logging: Programmable process parameter recording 

Coflore RTR with Enclosure

The Coflore RTR employs inertia-generated radial mixing that gives high performance mixing without the need for rotating drive shafts, mechanical seals or wall-mounted baffles.   Such advancements overcome difficulties in mixing that can be present in flow designs when processing higher volumes and throughputs.  This leads to a simple but effective design that also overcomes blocking and fouling, issues that have traditionally been associated with continuous flow reactors.

The axial blades rotate in reciprocating cycles to give self-baffling and radial mixing.  Maximum turbulence and shear conditions exist at the very outer region of the tube to optimise multi-phase handling characteristics. This delivers short mixing times, excellent mass-transfer conditions and optimum heat-transfer capability, whilst eliminating back-mixing to maintain orderly flow. Mixing is independent of residence time and is unaffected by flow velocity. As with all actively-mixed flow reactors from AM Technology, residence time is adjusted by the flow rate of the pump, without the need for configurational changes to the reactor itself.

Size comparison: Coflore RTR vs 7000 L batch reactor. For a 5 min residence time, the Coflore RTR can process >28,000 L in 24 h

Coflore RTR with Enclosure

Coflore RTR without Enclosure

Coflore RTR Reactor End Flange

Video close up of RTR tube's rotational agitation

Coflore RTR Reactor End Flange

Coflore RTR Facility Installation

Coflore RTR Digital Control Features and Specifications​:

  • Temperature Display with up to 8 temperature inputs and 8 temperature displays

  • Programmable alarm for high and low temperature set points

  • Ethernet connection enabling remote control via PC

  • Start/Stop agitation with 3 speeds

  • Remote DCS/PLC interface for remote agitation control with local and remote emergency stop

  • Data logging for process monitoring & data export to MS Excel

  • ATEX certification and CFR21 compliance options available on request

Coflore RTR Control System Specifications:

  • Drive Motor: 3.3 kW

  • Power Supply: 3ph+E+N

  • Control System: Schneider PLC & HMI

  • ATEX: ATEX Zone II option available

Coflore RTR Technical Specifications​:

  • Total Reactor Mass (empty): 530 kg

  • Reactor Volume: 100 L

  • Heat Transfer Area: 1.5 m2

  • Heat Transfer Zones: 3

  • Material Options: SS316, Hastelloy C276

  • Operating Pressure: FV/10 Bar

  • Operating Temperature: - 40 to 150 ˚C

  • Noise: < 70 dBA

Coflore RTR Dimensions:

  • Height: 1940 mm

  • Width:  2250 mm

  • Length: 1200 mm

  • Reactor Tube ID:          264 mm

  • Reactor Tube Length:  1800 mm

Coflore RTR Flow Reactor Operation
AM Technology, Cheshire, UK
+44 1928 237420