Scalable Continuous Manufacturing for High-Value Chemistry
Industry drivers, such as supply chain security and environmental regulation, are forcing the chemical and pharmaceutical industries to relook at their methods of production. Continuous manufacturing offers a clear opportunity towards safer, cleaner, and cheaper manufacturing.
Coflore:
The platform behind competitive manufacturing
Coflore Flow Reactor Systems by AM Technology are designed and manufactured specifically for the needs of the fine chemical and pharmaceutical industries.
The majority of chemical processes are multiphasic (e.g. liquid-solid, liquid-gas, liquid-solid-gas), yet the majority of continuous reactors on the market are incompatible with the presence of solids (resulting in blockages). Coflore employs patented “Dynamic Mixing” to overcome this key limitation, positioning the technology to be as versatile as batch reactor technology, but with an enhanced safety, environmental, and operating cost profile.
Patented Coflore Dynamic Mixing Technology unlocks the benefits of continuous flow to a wide range of chemical processes from benchtop R&D to multi-tonne production plants.
Why Manufacture with Continuous Flow Reactors?
1. Operational Cost Variance
With Europe facing 2x higher energy costs than major manufacturing hubs and labour up to 10x higher than Asia, continuous manufacturing offers a step-change: 20–30x lower peak power demand and 20–50% lower OPEX.
2. Improved Safety
Smaller working volumes and vastly improved heat transfer coefficients vs batch minimise risks of hazardous chemistry.
3. Environmental Regulatory Landscape
With the EU targeting 90% reduction in net greenhouse gas emissions by 2040, manufacturers face rising compliance pressure. Continuous manufacturing delivers up to 33% less waste, 50% smaller footprints, and CO₂ reductions of up to 80%.
4. Supply Chain Resilience
Covid and geopolitical instability have exposed the fragility of the global supply chain. Governments in import-dependent regions are pushing for local production. Continuous manufacturing supports this shift with minimal infrastructure needs and compact, modular plants that can be deployed quickly.
Coflore Continuous Flow Reactor Range
Laboratory Scale
100 mL Reactor Volume
Pilot / Production Scale
10 L Reactor Volume
Production Scale
100 L Reactor Volume
Grams / Kilograms
Kilograms / Tonnes
Tonnes / Kilotonnes
An actively mixed, bench-top continuous flow reactor, for developing and optimizing chemical processes in flow, or for when limited quantities of reactants or material are available or required. The Coflore ACR reactor process channel is divided into ten reactor cells, equivalent to ten CSTRs in series for plug flow.
For a 5-minute residence time, the Coflore ACR produces 1.2 L of material per hour.
A variable volume tubular continuous flow reactor of up to eight reactor tubes in series for plug flow (0.35 to 10 L reactor volume). Directly scalable from the Coflore ACR, with active mixing technology, to produce material at pilot and production scales.
For a 5-minute residence time, the Coflore ATR produces 120 L of material per hour.
A 100 L production scale continuous flow reactor, capable of processing countless reactor volumes without interruption. Such throughputs have the potential to produce many thousands of tons of material per year from a single reactor. The Coflore RTR operates as a ten-stage, actively mixed, and self-baffling plug flow reactor.
For a 5-minute residence time, the Coflore RTR produces 1,200 L of material per hour.
Continuous Flow Chemistry Testing Services
Have an existing chemical process that you would like to translate into flow?
AM Technology offer a range of flow chemistry testing services at our head offices in Cheshire, UK. Our state-of-the-art laboratories are well-equipped with analytical and process equipment to test and assess customer-specific processes at both R&D and Pilot-Plant scale.
Our multidisciplinary team of experts will design, setup and carry out experiments according to your own specific requirements, with submission of a full report of our findings on completion.
We can assist in converting existing batch processes into flow or alternatively work with your team to develop novel processes directly in flow.
Contact our technical team through our contact us form here, or by email at Info@amt.uk to find out more.
Continuous Flow Reactor Engineering Services
Our Coflore range of continuous flow reactors offers a clear pathway for scaling up chemical processes from R&D to multi-tonne scale.
Our in-house team consists of chemists, chemical, mechanical and electrical engineers as well as project managers who have years of experience taking chemical processes through from R&D to fully commissioned continuous flow chemical plants.
We can assist at every stage, and our engineering services are the perfect follow on from chemical feasibility / optimisation testing.
Contact our technical team through our contact us form here, or by email at Info@amt.uk to find out more.
