One of the fundamental differences between traditional batch process chemistry, and continuous process chemistry in flow is the concept of a reactor residence time (RT). The residence time is time that your reaction mixture spends within the reactor. The slower you pump reagents through a reactor, the longer they spend within the reactor and therefore the longer the residence time. Understanding the residence time of your chemical process within a flow reactor allows you to calculate the potential throughput that can be achieved once the system is running at steady-state.
ATR Residence Time Calculator
The working reactor volume of the Coflore ATR can be altered through changing the ATR reactor tube volume (either 0.35 L or 1.25 L) and the number of ATR reactor tubes in total on the platform (between 1 and 8).
Use the calculator below to easily workout the reaction mixture throughput for a Coflore ATR depending on the size and quantities of ATR reactor tubes, and the residence time of your chemical process.
ATR Pump Flowrate Calculator
The calculator below allows you to calculate the pump flowrates required to achieve a desired reaction residence time in the Coflore ATR. Remember - if you are feeding in multiple reagents at different points (i.e. reagent 1 at ATR tube 1, reagent 2 at ATR tube 2), then the working reactor volume for the purpose of calculating your required reaction residence time will be the number of ATR tubes downstream of the final reagent addition point.
“One of today's most important tools for modernizing the pharmaceutical industry is a process known as continuous manufacturing”
Director of the FDA’s Center for Drug Evaluation and Research, Janet Woodcock M.D.