Coflore Flow Reactors

Publications

2022

Physical and numerical characterisation of an agitated tubular reactor (ATR) for intensification of chemical processes

Hugh P. Rice, Yi He, Frans L. Muller, Andrew E. Bayly, Robert Ashe,
Andrew Karras, Ali Hassanpour, Richard A. Bourne, Michael Fairweather, Timothy N. Hunter

2022

Continuous-flow synthesis of the nucleobase unit of remdesivir

Yongxing Guo, Minjie Liu, Meifen Jiang, Yuan Tao, Dang Cheng, Fener Chen

2022

Eco-friendly processes for the synthesis of amorphous calcium carbonate nanoparticles in ethanol and their stabilisation in aqueous media

Lauriane Chuzeville, Frank Boury, David Duday, Resmi Anand, Enzo Moretto and Jean-Sébastien Thomann

2021

Effective Phosphorylation of 2,2′-Methylene-bis(4,6-di-tert-butyl) Phenol in Continuous Flow Reactors

Hanlin Yao, Li Wan, Xiaoyu Zhao, Yahui Guo, Jian Zhou, Xiaofan Bo, Yuxin Mao, and Zhong Xin*

2021

Coagulated Mineral Adsorbents for Dye Removal, and Their Process Intensification Using an Agitated Tubular Reactor (ATR)

Alastair S. Tonge, David Harbottle, Simon Casarin, Monika Zervaki, Christel Careme and Timothy N. Hunter

2021

Kinetic Studies of Cs+ and Sr2+ Ion Exchange Using Clinoptilolite in Static Columns and an Agitated Tubular Reactor (ATR)

Muhammad Yusuf Prajitno, Mohamad Taufiqurrakhman, David Harbottle and Timothy N. Hunter

2020

Flow behaviour of an agitated tubular reactor using a novel dynamic mesh based CFD model

Yi He, Andrew E. Bayly, Ali Hassanpour, Michael Fairweather, Frans Muller

2017

A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic

Marcus Baumann, Ian R. Baxendale and Fabien Deplante

2017

Characterization of a continuous agitated cell reactor for oxygen dependent biocatalysis

Asbjørn Toftgaard Pedersen, Teresa Melo de Carvalho, Euan Sutherland, Gustav Rehn, Robert Ashe, John M. Woodley

2014

Continuous flow synthesis of chiral amines

Breen, JR, Blacker, J, Gasparini, G et al.

2022

Continuous flow process for preparing budesonide

Manjinder Singh Phull, Surender Singh Jadav, Chander Singh Bohara, Rambabu Gundla, Prathama S Mainkar

2022

Development of a Fully Continuous-Flow Approach Towards Asymmetric Total Synthesis of Tetrahydroprotoberberine Natural Alkaloids

Weijian Li, Meifen Jiang, Minjie Liu, Xu Ling, Yingqi Xia, Li Wan, Fener Chen

2021

Fully Continuous Flow Synthesis of 5-(Aminomethyl)-2-methylpyrimidin-4-amine: A Key Intermediate of Vitamin B1

Meifen Jiang, Minjie Liu, Huashan Huang, and Fener Chen*

2021

Solvent Extraction and Mass Transfer Assessment in Novel Extraction Technologies

James Miller

2021

Continuous Sugar Beet Pulp Pretreatment and Bioconversion in a Biorefinery Context

Roberto Chiocchio

2020

A facile and practical Amination of 4-Fluoronitrobenzene in continuous flow

Zhilong Luo, Xije Wang, Xinchen Fan, Chao Kang, Yang Su, Yaoxuan Zhang & Song Chen

2018

Continuous Flow Process for Reductive Deoxygenation of ω-Chloroketone in the Synthesis of Vilazodone

Avedis Karadeolian, Dineshkumar Patel, Prabhudas Bodhuri, Gamini Weeratunga, and Boris Gorin

2017

Sustainable Flow Synthesis of a Versatile Cyclopentenone Building Block

Marcus Baumann, Ian R. Baxendale, Paolo Filipponi, and Te Hu

2015

Controlled Flow Precipitation as a Valuable Tool for Synthesis

Paolo Filipponi, Antimo Gioiello, and Ian R. Baxendale

“One of today's most important tools for modernizing the pharmaceutical industry is a process known as continuous manufacturing”

Director of the FDA’s Center for Drug Evaluation and Research, Janet Woodcock M.D.