Coflore Publications
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Coflore Flow Reactors

Publications

2025

Machine Learning-Driven Kinetic Elucidation for Sustainable Solvent-Free Continuous ε-Caprolactone Production via Propionaldehyde-Mediated Nanocarbon Catalysis

Qing Hu, Jiangnan Huang,* Hongjuan Wang, Siyu Yang,* Hao-Fan Wang, Shuang Li, Yonghai Cao,* Hao Yu

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2025

Sustainable and Scalable Amidations in Water Using Continuous Slurry-Flow Technology

Sri Hari Anandhi Rajendran, Sabrina Kogler, Philipp Kögl, Wilfried M. Braje, Sándor B. Ötvös,* C. Oliver Kappe*

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2024

Intensified co-precipitation and ion exchange using an agitated tubular reactor (ATR) for enhanced removal of Cs+ and Sr2+ ions

Oguzhan Kivan, Muhammad Yusuf, Rachael Filson-Halliwell, Jennifer N. Enemmoh, David Harbottle, Timothy N. Hunter

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2023

Opportunities for Process Intensification Technologies in Nuclear Effluent Treatment: A Review of Precipitators, Adsorbers and Separators

G. Yaghy, A.S. Tonge, H. Abouhakim, R. Peeling, M. Talford, L. O'Brien, A. Paksy, P. Nevitt, F.L. Muller, B.C. Hanson, T.N. Hunter

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2022

Process intensification of dendritic fibrous nanospheres of silica (DFNS) via continuous flow: a scalable and sustainable alternative to the conventional batch synthesis

Karuna Veeramani, Nagaraj Nayak, Neil R. Cameron and Anil Kumar

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2022

Physical and numerical characterisation of an agitated tubular reactor (ATR) for intensification of chemical processes

Hugh P. Rice, Yi He, Frans L. Muller, Andrew E. Bayly, Robert Ashe,
Andrew Karras, Ali Hassanpour, Richard A. Bourne, Michael Fairweather, Timothy N. Hunter

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2022

Continuous flow process for preparing budesonide

Manjinder Singh Phull, Surender Singh Jadav, Chander Singh Bohara, Rambabu Gundla, Prathama S Mainkar

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2022

Development of a Fully Continuous-Flow Approach Towards Asymmetric Total Synthesis of Tetrahydroprotoberberine Natural Alkaloids

Weijian Li, Meifen Jiang, Minjie Liu, Xu Ling, Yingqi Xia, Li Wan, Fener Chen

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2021

Fully Continuous Flow Synthesis of 5-(Aminomethyl)-2-methylpyrimidin-4-amine: A Key Intermediate of Vitamin B1

Meifen Jiang, Minjie Liu, Huashan Huang, and Fener Chen*

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Link to Publication

2021

Solvent Extraction and Mass Transfer Assessment in Novel Extraction Technologies

James Miller

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2021

Continuous Sugar Beet Pulp Pretreatment and Bioconversion in a Biorefinery Context

Roberto Chiocchio

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2020

A facile and practical Amination of 4-Fluoronitrobenzene in continuous flow

Zhilong Luo, Xije Wang, Xinchen Fan, Chao Kang, Yang Su, Yaoxuan Zhang & Song Chen

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2018

Continuous Flow Process for Reductive Deoxygenation of ω-Chloroketone in the Synthesis of Vilazodone

Avedis Karadeolian, Dineshkumar Patel, Prabhudas Bodhuri, Gamini Weeratunga, and Boris Gorin

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2017

Sustainable Flow Synthesis of a Versatile Cyclopentenone Building Block

Marcus Baumann, Ian R. Baxendale, Paolo Filipponi, and Te Hu

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2015

Controlled Flow Precipitation as a Valuable Tool for Synthesis

Paolo Filipponi, Antimo Gioiello, and Ian R. Baxendale

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2012

Biocatalytic oxidase: Batch to continuous

Edward Jones, Kay McCleana, Sally Housdena, Gilda Gasparini, Ian Archer

Link to Publication

2025

Continuous Crystallization of Atorvastatin Calcium at a Multitonnage Scale Using Dynamically Mixed Flow Reactors for Target Polymorph Control

Naga Lakshmi Ramana Susarla, Dharma Jaganadha Rao Velaga, Mohammed Yakoob Sardar, Anirban Ghosh, Ravi Kumar Gorle, Suhas Jawlekar, Rajeev Rehani Budhdev, Srividya Ramakrishnan*

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2025

Elucidating the Influence of N Doping on Production of ε-Caprolactone Catalyzed by Nanocarbon: A Kinetic Model from Batch to Semibatch and Continuous-Flow Operations

Zhihui Cai, Mengzhi Yuan, Hongjuan Wang, Hao-Fan Wang, Shuang Li, Yonghai Cao* Hao Yu, Feng Peng

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2024

Establishment and Development of Organolithium-Mediated Continuous Flow Process for Intermediate of Canagliflozin

Gemba Yano*, Mai Hyakumura, Kimihiro Nakano, Hiroaki Yasukouchi*, Hideo Kawachi, Makoto Funabashi, Takahiro Ohishi, Yu Ogawa, and Akira Nishiyama

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2023

Preparation of (3R)-quinuclidinol using heterogeneous biocatalytic hydrogenation in a dynamically-mixed continuous flow reactor

Sarah E. Cleary, Sofia Kazantzi, Joshua Trenchard, Martin Monedero, Jack W. Allman, Tara C. Lurshay, Xu Zhao, Michael B. Kenny and Holly A. Reeve

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2022

Process Intensification Techniques For Combined Cooling & Antisolvent Crystallization Of Drug Substances

Shivani A Kshirsagar

Link to Publication

2022

Flow chemistry in the multi-step synthesis of natural products

Li Wan, Gaopan Kong, Minjie Liu, Meifen Jiang, Dang Cheng, Fener Chen

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2022

Continuous-flow synthesis of the nucleobase unit of remdesivir

Yongxing Guo, Minjie Liu, Meifen Jiang, Yuan Tao, Dang Cheng, Fener Chen

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2022

Eco-friendly processes for the synthesis of amorphous calcium carbonate nanoparticles in ethanol and their stabilisation in aqueous media

Lauriane Chuzeville, Frank Boury, David Duday, Resmi Anand, Enzo Moretto and Jean-Sébastien Thomann

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2021

Effective Phosphorylation of 2,2′-Methylene-bis(4,6-di-tert-butyl) Phenol in Continuous Flow Reactors

Hanlin Yao, Li Wan, Xiaoyu Zhao, Yahui Guo, Jian Zhou, Xiaofan Bo, Yuxin Mao, and Zhong Xin*

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2021

Coagulated Mineral Adsorbents for Dye Removal, and Their Process Intensification Using an Agitated Tubular Reactor (ATR)

Alastair S. Tonge, David Harbottle, Simon Casarin, Monika Zervaki, Christel Careme and Timothy N. Hunter

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Link to Publication

2021

Kinetic Studies of Cs+ and Sr2+ Ion Exchange Using Clinoptilolite in Static Columns and an Agitated Tubular Reactor (ATR)

Muhammad Yusuf Prajitno, Mohamad Taufiqurrakhman, David Harbottle and Timothy N. Hunter

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2020

Flow behaviour of an agitated tubular reactor using a novel dynamic mesh based CFD model

Yi He, Andrew E. Bayly, Ali Hassanpour, Michael Fairweather, Frans Muller

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2017

A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic

Marcus Baumann, Ian R. Baxendale and Fabien Deplante

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2017

Characterization of a continuous agitated cell reactor for oxygen dependent biocatalysis

Asbjørn Toftgaard Pedersen, Teresa Melo de Carvalho, Euan Sutherland, Gustav Rehn, Robert Ashe, John M. Woodley

Link to Publication

2014

Continuous flow synthesis of chiral amines

Breen, JR, Blacker, J, Gasparini, G et al.

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2012

Scaling Up Biocatalysis Reactions in Flow Reactors

Gilda Gasparini, Ian Archer, Ed Jones, and Robert Ashe

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“One of today's most important tools for modernizing the pharmaceutical industry is a process known as continuous manufacturing”

Director of the FDA’s Centre for Drug Evaluation and Research,

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