Coflore Flow Reactors

Publications

Please check back to this page regularly as it will be constantly updated.

If you have published work utilising a Coflore Flow Reactor, please let us know and we will be more than happy to add it to this list.

Publications

2022

Continuous flow process for preparing budesonide

Manjinder Singh Phull, Surender Singh Jadav, Chander Singh Bohara, Rambabu Gundla, Prathama S Mainkar

Link to Publication: https://doi.org/10.1007/s41981-022-00221-5

Development of a Fully Continuous-Flow Approach Towards Asymmetric Total Synthesis of Tetrahydroprotoberberine Natural Alkaloids

Weijian Li, Meifen Jiang, Minjie Liu, Xu Ling, Yingqi Xia, Li Wan, Fener Chen

Link to Publication: https://doi.org/10.1002/chem.202200700

Continuous-flow synthesis of the nucleobase unit of remdesivir

Yongxing Guo, Minjie Liu, Meifen Jiang, Yuan Tao, Dang Cheng, Fener Chen

Link to Publication: https://doi.org/10.1016/j.eng.2021.07.029

Eco-friendly processes for the synthesis of amorphous calcium carbonate nanoparticles in ethanol and their stabilisation in aqueous media

Lauriane Chuzeville, Frank BouryDavid DudayResmi AnandEnzo Moretto and Jean-Sébastien Thomann

Link to Publication: https://doi.org/10.1039/D1GC03396D

2021

Continuous Sugar Beet Pulp Pretreatment and Bioconversion in a Biorefinery Context

Roberto Chiocchio

Link to PhD Thesis: https://discovery.ucl.ac.uk/id/eprint/10139025/

Solvent Extraction and Mass Transfer Assessment in Novel Extraction Technologies

James Miller

Link to PhD Thesis: https://etheses.whiterose.ac.uk/29223/

Effective Phosphorylation of 2,2′-Methylene-bis(4,6-di-tert-butyl) Phenol in Continuous Flow Reactors
Hanlin Yao, Li Wan, Xiaoyu Zhao, Yahui Guo, Jian Zhou, Xiaofan Bo, Yuxin Mao, and Zhong Xin*

Link to Publication: https://pubs.acs.org/doi/10.1021/acs.oprd.1c00105

Fully Continuous Flow Synthesis of 5-(Aminomethyl)-2-methylpyrimidin-4-amine: A Key Intermediate of Vitamin B1
Meifen Jiang, Minjie Liu, Huashan Huang, and Fener Chen*

Link to Publication: https://doi.org/10.1021/acs.oprd.1c00253

Kinetic Studies of Cs+ and Sr2+ Ion Exchange Using Clinoptilolite in Static Columns and an Agitated Tubular Reactor (ATR)
Muhammad Yusuf Prajitno, Mohamad Taufiqurrakhman, David Harbottle and Timothy N. Hunter

Link to Publication: https://www.mdpi.com/2305-7084/5/1/9

Coagulated Mineral Adsorbents for Dye Removal, and Their Process Intensification Using an Agitated Tubular Reactor (ATR)
Alastair S. Tonge, David Harbottle, Simon Casarin, Monika Zervaki, Christel Careme and Timothy N. Hunter

Link to Publication: https://www.mdpi.com/2305-7084/5/3/35

Pre 2021

Continuous Flow Process for Reductive Deoxygenation of ω-Chloroketone in the Synthesis of Vilazodone

Link to Publication: https://pubs.acs.org/doi/10.1021/acs.oprd.8b00145

A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic
Marcus Baumann, Ian R. Baxendale and Fabien Deplante

Link to Publication: https://www.beilstein-journals.org/bjoc/articles/13/251

Controlled Flow Precipitation as a Valuable Tool for Synthesis
Paolo Filipponi†, Antimo Gioiello‡, and Ian R. Baxendale*†

Link to Publication: https://pubs.acs.org/doi/10.1021/acs.oprd.5b00331

Characterization of a continuous agitated cell reactor for oxygen dependent biocatalysis
Asbjørn Toftgaard Pedersen, Teresa Melo de Carvalho, Euan Sutherland, Gustav Rehn, Robert Ashe, John M. Woodley

Link to Publication: https://onlinelibrary.wiley.com/doi/10.1002/bit.26267

Notable Reviews

Continuous flow technology-a tool for safer oxidation chemistry

Li WanMeifen JiangDang ChengMinjie Liua and Fener Chen

Link to Review: https://pubs.rsc.org/en/content/articlelanding/2022/RE/D1RE00520K

Machine-Assisted Organic Synthesis
Prof. Steven V. Ley, Daniel E. Fitzpatrick, Dr. Rebecca M. Myers, Dr. Claudio Battilocchio, Dr. Richard. J. Ingham

Link to Review: https://onlinelibrary.wiley.com/doi/10.1002/anie.201501618

Continuous flow biocatalysis
Joshua Britton, Sudipta Majumdar and Gregory A. Weiss 

Link to Review: https://pubs.rsc.org/en/content/articlelanding/2018/CS/C7CS00906B

Handling diazonium salts in flow for organic and material chemistry
Nicolas Oger, Erwan Le Grogneca and François-Xavier Felpin

Link to Review: https://pubs.rsc.org/en/content/articlelanding/2015/QO/C5QO00037H

“One of today's most important tools for modernizing the pharmaceutical industry is a process known as continuous manufacturing”

Director of the FDA’s Center for Drug Evaluation and Research, Janet Woodcock M.D.