Coflore Flow Reactors

Publications & Case Studies

Please check back to this page regularly as it will be constantly updated.

If you have published work utilising a Coflore Flow Reactor, please let us know and we will be more than happy to add it to this list.



Effective Phosphorylation of 2,2′-Methylene-bis(4,6-di-tert-butyl) Phenol in Continuous Flow Reactors
Hanlin Yao, Li Wan, Xiaoyu Zhao, Yahui Guo, Jian Zhou, Xiaofan Bo, Yuxin Mao, and Zhong Xin*

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Fully Continuous Flow Synthesis of 5-(Aminomethyl)-2-methylpyrimidin-4-amine: A Key Intermediate of Vitamin B1
Meifen Jiang, Minjie Liu, Huashan Huang, and Fener Chen*

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Kinetic Studies of Cs+ and Sr2+ Ion Exchange Using Clinoptilolite in Static Columns and an Agitated Tubular Reactor (ATR)
Muhammad Yusuf Prajitno, Mohamad Taufiqurrakhman, David Harbottle and Timothy N. Hunter

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Coagulated Mineral Adsorbents for Dye Removal, and Their Process Intensification Using an Agitated Tubular Reactor (ATR)
Alastair S. Tonge, David Harbottle, Simon Casarin, Monika Zervaki, Christel Careme and Timothy N. Hunter

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Pre 2021

Continuous Flow Process for Reductive Deoxygenation of ω-Chloroketone in the Synthesis of Vilazodone

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A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic
Marcus Baumann, Ian R. Baxendale and Fabien Deplante

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Controlled Flow Precipitation as a Valuable Tool for Synthesis
Paolo Filipponi†, Antimo Gioiello‡, and Ian R. Baxendale*†

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Characterization of a continuous agitated cell reactor for oxygen dependent biocatalysis
Asbjørn Toftgaard Pedersen, Teresa Melo de Carvalho, Euan Sutherland, Gustav Rehn, Robert Ashe, John M. Woodley

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Notable Reviews

Machine-Assisted Organic Synthesis
Prof. Steven V. Ley, Daniel E. Fitzpatrick, Dr. Rebecca M. Myers, Dr. Claudio Battilocchio, Dr. Richard. J. Ingham

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Continuous flow biocatalysis
Joshua Britton, Sudipta Majumdar and Gregory A. Weiss 

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Handling diazonium salts in flow for organic and material chemistry
Nicolas Oger, Erwan Le Grogneca and François-Xavier Felpin

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Case Studies & Technical Notes

We are currently in the process of updating our internal case studies. Please bear with us.


Bourne Reaction Characterisation of the Coflore ACR

AMT TN-01 Supplementary Report

Fast Competitive Chemical Reactions within the Agitated Cell Reactor


Slurry Handling Within the Coflore ACR - Case Study 1

“One of today's most important tools for modernizing the pharmaceutical industry is a process known as continuous manufacturing”

Director of the FDA’s Center for Drug Evaluation and Research, Janet Woodcock M.D.