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Calcium Carbonate Slurry Recycling in the Coflore® ACR

AM Technology have published a new technical note summarising results from a recent internal study to investigate high weight % slurry handling within the Coflore® ACR.

When assessing the suitability of solid-liquid reactions in flow, the characteristics of the solid have a large impact on the reaction set up required. In particular, the settling characteristics of a solid has a significant impact, with fast-settling solids behaving very differently to slow-settling solids in flow.

A typical slurry recycling set up for the ACR, with both the inlet and outlet tubing placed within a feed vessel

Calcium carbonate is an ideal solid to work with due to its non-hazardous properties and insolubility in water. Calcium carbonate has a density of 2.71 g/mL and is relatively slow-settling in water. This latest internal testing at AM Technology investigated the ability of an ACR to handle a >60%w/v suspension of calcium carbonate, at 1 minute, 2 minute and 5 minute residence times and over extended run times.

At all three residence times investigated, no accumulation of solids within the ACR was observed. The total run time for the testing was 120 h.

You can download this latest technical note (AMT-TN03) from our publications and case studies section, here, or through the download link below.

Download PDF • 531KB


“One of today's most important tools for modernizing the pharmaceutical industry is a process known as continuous manufacturing”

Director of the FDA’s Centre for Drug Evaluation and Research,

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